Uromodulin oder: Was «geschah» mit dem Tamm-Horsfall-Protein?
نویسندگان
چکیده
منابع مشابه
Immunomodulatory properties of Tamm-Horsfall glycoprotein (THP) and uromodulin.
BACKGROUND Tamm-Horsfall glycoprotein (THP) and uromodulin are the most abundant glycoproteins in non-pregnant women's/men's and pregnant women's urine, respectively. However, the bioactivities of these glycoproteins are still unclear. OBJECTIVE To evaluate the immunomodulatory properties of THP and uromodulin on human peripheral blood mononuclear cells (PBMC) METHODS: THP and uromodulin isol...
متن کاملEvaluation of Glycan Profiles of Tamm-horsfall Glycoprotein and Uromodulin
Uromodulin is well-known to be the more potent immunosuppressive glycoprotein isolated from pregnant women urine, compared to its counterpart, Tamm-Horsfall glycoprotein (THP) isolated from non-pregnant women/male urine. However, structural profiles of these glycoproteins were controversial until today. Hence, this paper aims to identify the pregnancy associated glycosylation changes of THP and...
متن کاملRole of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization.
One of the defenses against nephrolithiasis is provided by macromolecules that modulate the nucleation, growth, aggregation and retention of crystals in the kidneys. The aim of the present study was to determine the behavior of two of these proteins, Tamm-Horsfall and uromodulin, in calcium oxalate crystallization in vitro. We studied a group of 10 male stone formers who had formed at least one...
متن کاملTamm-Horsfall protein or uromodulin: new ideas about an old molecule.
More than 50 years ago, Tamm and Horsfall isolated a mucoprotein from the human urine, and showed that the protein was able to interact and inhibit viral haemagglutination [1,2]. Of interest, the protein was found to be heavily glycosylated, containing up to 30% of its mass in carbohydrates [3]. It was then discovered that the Tamm–Horsfall protein (THP), as it was readily named, was the most a...
متن کاملThe rediscovery of uromodulin (Tamm-Horsfall protein): from tubulointerstitial nephropathy to chronic kidney disease.
Uromodulin (Tamm-Horsfall protein) is the most abundant protein excreted in the urine under physiological conditions. It is exclusively produced in the kidney and secreted into the urine via proteolytic cleavage. Its biological function is still not fully understood. Uromodulin has been linked to water/electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrate...
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ژورنال
عنوان ژورنال: Swiss Medical Forum ‒ Schweizerisches Medizin-Forum
سال: 2014
ISSN: 1424-4020,1424-3784
DOI: 10.4414/smf.2014.02031